I am probably the last person on earth to read the IST-3 trial. In short, the authors’ conclusion of ´strong support for thrombolytics in stroke´ was
pisspreik somewhat controversial and generated some discussion.
Read this excellent post about the IST-3 trial and thrombolysis in stroke in general on ED Trauma Critical Care. There is also a good list of links, resources and comments on the IST-3 trial. Among the comments:
“…In a secondary analysis (which means – since we found no significant benefit, this is how we manipulated the data to make it appear so)….”