What will it take for dopamine to go away? There’s the problems with tachycardia, arrhythmias, increased metabolism and reports of it being immunosuppressive. And with the diuresis edge debunked, it is very hard to motivate a place in our arsenal. Yet, in many places, it’s still considered a first choice vasopressor in septic patients. Here’s yet another study that snipes at dopamine. And yes it’s that doctor De Backer again. He is to dopamine what Van Helsing is to Dracula.
The article just published in Crit Care Med 2012 vol 40 is a metaanalysis of studies comparing dopamine and noradrenaline. Out of those studies De Backer et al retrieved 2768 patients. The researchers observed how dopamine was associated with a greater mortality and a higher incidence of arrhythmic events compared to noradrenaline.
It’s here. Abstract below.